MYELOID NEOPLASIA Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia
نویسندگان
چکیده
*Carsten Müller-Tidow,1,2 *Hans-Ulrich Klein,3 Antje Hascher,1,2 Fabienne Isken,1 Lara Tickenbrock,1,4 Nils Thoennissen,1 Shuchi Agrawal-Singh,1,2 Petra Tschanter,1,2 Christine Disselhoff,1 Yipeng Wang,5 Anke Becker,6 Christian Thiede,7 Gerhard Ehninger,7 Udo zur Stadt,8 Steffen Koschmieder,1 Matthias Seidl,9 Frank U. Müller,9 Wilhelm Schmitz,9 Peter Schlenke,10 Michael McClelland,5 Wolfgang E. Berdel,1 *Martin Dugas,3 and *Hubert Serve,1,11 on behalf of the Study Alliance Leukemia
منابع مشابه
Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia.
BACKGROUND The EVI1 gene (3q26) codes for a zinc finger transcription factor with important roles in both mammalian development and leukemogenesis. Over-expression of EVI1 through either 3q26 rearrangements, MLL fusions, or other unknown mechanisms confers a poor prognosis in acute myeloid leukemia. DESIGN AND METHODS We analyzed the prevalence and prognostic impact of EVI1 over-expression in...
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EZH2, a catalytic component of the polycomb repressive complex 2, trimethylates histone H3 at lysine 27 (H3K27) to repress the transcription of target genes. Although EZH2 is overexpressed in various cancers, including some hematologic malignancies, the role of EZH2 in acute myeloid leukemia (AML) has yet to be examined in vivo. In the present study, we transformed granulocyte macrophage progen...
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